6 Supplements and Vitamins for Acid Reflux

Acid reflux is a common digestive issue associated with side effects like heartburn, belching, and nausea. This article explores supplements that can help you reduce these symptoms.

Supplements and Vitamins for Acid Reflux

These are 6 supplements you can use to treat acid reflux:

Betaine HCI with Pepsin

Betaine hydrochloride (HCI) is a compound used to boost stomach acid. If you have low stomach acid levels, it can lead to slow digestion and nutrient absorption. Betaine hydrochloride is also combined with pepsin in many supplements. This digestive enzyme in your stomach acid breaks proteins into smaller units.

However, the U.S. Food and Drug Administration (FDA) has concluded there is not enough evidence supporting the effectiveness of betaine HCI or pepsin in increasing stomach acidity.

B Vitamins

Based on a study, increased intake of multiple B vitamins can reduce your risk of reflux esophagitis. This condition is characterized by inflammation in your esophagus caused by acid reflux.

Additionally, greater intakes of vitamin B6 and folate can reduce your risk of esophagus cancer and Barrett’s esophagus. These are both potential complications of long-term GERD. However, you must remember that B vitamins are just one supplement component. This means the effect of B vitamins remains unclear.


Iberogast is a supplement commonly used to treat acid reflux and irritable bowel syndrome. It is made from blended herbal extracts, including licorice root, peppermint, and milk thistle fruit.

According to a study of 272 people, Iberogast can greatly improve digestive symptoms within 15 minutes of the first dose. Furthermore, an animal study showed Iberogast is effective as a traditional antacid for decreasing stomach acidity.


Probiotics are a type of beneficial bacteria located in your digestive tract. According to research, supplementing with probiotics can decrease symptoms of acid reflux. For instance, a study combining heartburn medication with probiotics reduced the risk of treatment relapse.


Melatonin is a hormone that primarily regulates your sleep-wake cycle. Despite being majorly used to treat insomnia, studies have shown it can help treat acid reflux. For instance, a study of 36 people taking melatonin, either alone or with heartburn medication, for 4-8 weeks reduced symptoms of GERD.


Ginger is used as both a spice and a herbal supplement. It can soothe stomach trouble and treat issues like indigestion and nausea. According to one study, taking 3 grams of ginger powder daily for 4 weeks can improve indigestion symptoms.


There are multiple supplements you can use to solve your acid reflux. However, you need to confirm with your doctor if there are any possible side effects.